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Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa)

Selected publications  |  Contact details  |  Group members  |  Collaborations

Senior Group Leader at The Francis Crick Establish, London; and Wellcome Senior Fellow in Clinical Science at Purple College London [both posts seconded to the Academy of Cape Town]; Managing director, Eye for Infectious Diseases Inquiry in Africa (CIDRI-Africa); Group leader and Director, Crick African Network; and Fellow member, Found of Infectious disease and Molecular Medicine; Department of Medicine, Faculty of Health Sciences, Academy of Cape Town

Robert J. Wilkinson's interests are focused on clinical and immunological aspects of tuberculosis, specially in the context of HIV-1 infection.

HIV and TB are the near pressing public health issues in Africa: in South Africa, many hundreds of people notwithstanding die prematurely per mean solar day considering of HIV, many due to co-existent TB. The epidemiology and clinical features of HIV associated TB are well researched, but few studies have addressed in particular the cellular mechanisms. His research program derives its research questions from the clinical care of tuberculosis (TB) and HIV-TB co-infected persons in South Africa and London. Through clinically-based studies, they aim to improve noesis of pathogenesis and thereby improve prevention and treatment. Projects underway at present include the following:

How can tuberculosis infection in HIV infected people exist more than effectively prevented?

By what immune mechanisms practice preventive therapies decrease susceptibility to TB?

What is the cause and all-time management of the HIV-Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome? This project is led by Professor Graeme Meintjes, Professor and Infectious Diseases Physician, CIDRI-Africa, UCT.

What is the pathogenesis of tuberculous pericarditis?

How does HIV infection influence the immune responses to Mycobacterium tuberculosis in the lung?

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Selected publications:

Stucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, 50., Rutaihwa, L., Borrell, S., Luo, T., Gao, Q., Kato-Maeda, One thousand., Ballif, G., Egger, M., Macedo, R., Mardassi, H., Moreno, One thousand., Vilanova, Thousand.T., Fyfe, J., Globan, M., Thomas, J., Jamieson, F., Guthrie, J.L., Asante-Poku, A., Yeboah-Manu, D., Wampande, E., Ssengooba, W., Joloba, Chiliad., Boom, Westward.H., Basu, I., Bower, J., Saraiva, M., Vasconcellos, Due south.E.G., Suffys, P., Koch, A., Wilkinson, R., Gail-Bekker, L., Malla, B., Ley, Due south.D., Beck, H.-P., De Jong, B.C., Toit, Chiliad., Sanchez-Padilla, East., Bonnet, Chiliad., Gil-Brusola, A., Frank, M., Penlap Beng, 5.N., Eisenach, Grand., Alani, I., Ndung'U, P.Westward., Revathi, G., Gehre, F., Akter, Southward., Ntoumi, F., Stewart-Isherwood, L., Ntinginya, Northward.East., Rachow, A., Hoelscher, One thousand., Cirillo, D.Yard., Skenders, Chiliad., Hoffner, S., Bakonyte, D., Stakenas, P., Diel, R., Crudu, V., Moldovan, O., Al-Hajoj, Southward., Otero, 50., Barletta, F., Carter, E.J., Diero, L., Supply, P., Comas, I., Niemann, S., Gagneux, S. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Nature Genetics (2016) 48(12):1535-1543

Esmail, H., Lai, R.P., Lesosky, M., Wilkinson, K.A., Graham, C.M., Coussens, A.K., Oni, T., Warwick, J.M., Said-Hartley, Q., Koegelenberg, C.F., Walzl, 1000., Flynn, J.Fifty., Young, D.B., Barry, C.E., O'Garra, A., Wilkinson, R.J. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission and computed tomography. Nature Medicine (2016) 22(10):1090-1093

Lai, RPJ; Meintjes, G; Wilkinson, KA; Graham, CM; Marais, S; Van der Plas, H; Deffur, A; Schutz, C; Flower, C; Munagala, I; Anguiano, East; Goliath, R; Maartens, G; Banchereau, J; Chaussabel, D; O'Garra, A and Wilkinson, RJ. HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling. Nature Communications (2015) 6, 8451

Coussens, AK; Naude, CE; Goliath, R; Chaplin, Chiliad; Wilkinson, RJ and Jablonski, NG. High-dose vitamin D_three reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans. Proceedings of the National Academy of Sciences of the United states (2015) 112, 8052-8057

Anderson, S.T.B., Kaforou, Yard., Brent, A., Wright, V.J., Banwell, C.M., Chagaluka, Thousand., Crampin, A.C., Dockrell, H.M., French, Northward., Hamilton, M.South., Hibberd, Thou.Fifty., Kern, F., Langford, P.R., Ling, L., Mlotha, R., Ottenhoff, T.H.M., Pienaar, Southward., Pillay, 5., Scott, J.A.Grand, Twahir, H., Wilkinson, R.J., Coin, 50.J., Heyderman, R.South., Levin, M., Eley, B. Diagnosis of childhood tuberculosis and host RNA expression in Africa. New England Journal of Medicine (2014) 370:1712-23

Martineau, A.R., Nhamoyebonde, South., Oni, T., Rangaka, One thousand.X., Marais, Southward., Bangani, N., Tsekela, R., Bashe, L., de Azevedo, 5., Caldwell, J., Venton, T.R., Timms, P., Wilkinson, K.A., Wilkinson, R.J. Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa. Proceedings of the National Academy of Sciences of the U.s. (2011) 108(47):19013-7

Berry, 1000.P.R., Graham, C.M., McNab, F.West., Xu, Z., Bloch, Southward.J., Oni, T., Wilkinson, G.A., Banchereau, R., Skinner, J., Wilkinson, R.J., Quinn, C., Blankenship, D., Dhawan, R., Cush, J.J., Mejias, A., Ramilo, O., Kon, O.M., Pascual, 5., Banchereau, J., Chaussabel, D., and O'Garra, A. An Interferon-Inducible Neutrophil-Driven blood transcriptional signature in Man Tuberculosis. Nature (2010) 466: 973-977

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Contact details:

Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa)
Room 3.3.05, Wolfson Pavilion
Institute of Infectious Disease and Molecular Medicine
Faculty of Wellness Sciences
Academy of Cape Town
Observatory 7925
Southward Africa

Tel:  +27 21 406 6084
Fax: +27 21 406 6796

Email: robert.wilkinson@uct.air-conditioning.za
r.j.wilkinson@majestic.air conditioning.uk
robert.wilkinson@crick.ac.uk

Alternate sites:https://www.crick.ac.uk/inquiry/a-z-researchers/researchers-v-y/robert-j-wilkinson/
world wide web.cidri.uct.air conditioning.za

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Grouping members:

Postgraduate students and postdoctoral fellows
Dr	Abhimanyu	Abhimanyu	Postdoctoral Boyfriend
Dr	Du Bruyn	Elsa	Doctoral pupil
Ms	Goliath	Rene	Masters educatee
Mr	Moseki	Moeketsi Raymond	Doctoral Student
Mr	Ndengane	Mthawelanga	Doctoral Student
Dr	Peton	Nashied	Postdoctoral Fellow
Dr	Seeger	Allison	Postdoctoral Fellow
Ms	Sibiya	Nomfundo	Doctoral educatee
Staff
Ms	Bam	Veronica	Inquiry Nurse
Dr	Berkowitz	Natacha	Research Medical Officer
Dr	Coussens	Anna	Senior Lecturer in Pathology
Dr	Du Bruyn	Elsa	Research Medical Officer
Dr	Esmail	Hanif	Honorary Research Associate, UK
Ms	Gobe	Nonceba	Clinical Research Worker
Ms	Goliath	Rene	Projects Co-ordinator
Ms	Jackson	Amanda	Data Systems Manager
Mrs	Jan	Vanessa	Lab Manager
Mr	Kwaza	Bekekile	Clinical Research Worker
Mr	Lakay	Francisco	Senior Technical Officer
Ms	Letswalo	Kgothatso	Laboratory Technologist
Ms	Mashinyira	Antoneta	Data Control Co-ordinator
Ms	Mayiya	Mpume	Clinical Research Worker
Ms	McMaster	Meagan	Senior Data Capturer
Ms	Modolo	Khuthazwa	Enquiry Nurse
Mrs	Morar	Tania	Role time Pharmacist
Mrs	Morey	Erika	Administrative Assistant
Dr	Mukasa	Sandra	Research Medical Officer
Ms	Ngcuka	Thembisa	Clinical Inquiry Worker
Mrs	Omar-Davies	Nashreen	Radiographer
Dr	Rangaka	Molebogeng	Honorary Inquiry Associate, UK
Dr	Riou	Catherine	Senior Research Officer
Dr	Rockwood	Neesha	Honorary Research Associate, Britain
Ms	Ruzive	Sheena	Laboratory Technologist
Mr	Sindelo	Sicelo	Enquiry Nurse
Dr	Sossen	Bianca	Medical Research Officer
Ms	Thamae	Goitseone	Technical Officeholder
Dr	Thienemann	Friedrich	Senior Research Medical Officer
Mrs	Van Wyhe	Pamela	Banana Nurse
Hon. A/Prof	Wilkinson	Katalin	Senior Scientist, Associate Professor
Ms	Wood	Kathryn	Centre Operations Director
Mrs	Worship	Celeste	Information Capturer

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Collaborations:

Anne O'Garra, NIMR, U.k.

Clifton Earl Barry III, National Institutes of Health

Helen McShane, Oxford University

Alan Sher, National Institutes of Allergy and Infectious Diseases, United states

Jo-Anne Flynn, University of Pittsburgh, U.s.a.

Robert S Heyderman, University Higher London, UK

Gary Maartens, Division of Pharmacology and IDM, UCT

Bongani Mayosi, Department of Medicine and IDM, UCT

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Source: http://www.idm.uct.ac.za/Robert_Wilkinson

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